The first card is reversed Temperance, which indicates that there may be sudden and unforeseen changes in Mario's life. This can be good if the change is somehow motivated and driven by an inner strength. Temperance reversed also suggests that Mario may be open to new changes and new opportunities, despite the difficulties that may arise along the way.

The second card is Nine of Cups, which indicates that Mario may face obstacles or challenges in dealing with changes in his life. You may need to face fears and insecurities in order to move forward with plans for change. Furthermore, the Nine of Cups also suggests that Mario will need to make well thought out decisions before taking rash steps.

The third card is Two of Cups reversed, indicating that Mario's plans for change will not be easy to implement and will require commitment and energy. However, this downside can be mitigated by Mario's ability to use his creativity and imagination to come up with innovative solutions. In addition, the reversed Two of Cups also suggests that Mario may meet special people who will help him on his journey towards change.

Finally, the last card is reversed Six of Swords, indicating that Mario will have to face his fears and gather courage if he is to make a big change in his life. The advice of the reversed Six of Swords is therefore to embrace change with enthusiasm and confidence, aware of the possibility of failure but ready to face the challenges that may arise along the way.

From the analysis of the four tarot cards drawn, it seems probable that My Brother Mario will make a big change in his life in the future. However, there are some hurdles to overcome before achieving this goal. Mario will have to face his fears and take courage to embark on this journey towards change. The best answer to the question then is: Yes, my brother Mario will make a big change in his life in the future.